Rewriting the biology books! And I'm positive this is the only time we may see a press conference where the scientist credited with a profound discovery uttered the words, "I'd like to introduce to you, the bacteria." Later, one of the panel compared the discovery to the Horta on Star Trek (1967). I was quite nearly beside myself with the wonderfulness of this hour on NASA Television yesterday.

I kept my favorite space and technology blogs open in browser tabs, and a good percentage of them posted before the conference even reached the Q&A session, LOL! I'm not in that much of a hurry. I'd make a terrible "breaking news" reporter, because I like to ponder topics, discuss them at length, perhaps even allow for an R.E.M. phase before I develop an emotion about a newsworthy event.
Dr. Felisa Wolfe-Simon, in all her youthful, attractive, nose-pierced glory, was an eloquent and erudite speaker, who announced that her team discovered a microbe that can substitute arsenic for phosphorous. Everyone can enjoy reruns on NASA’s YouTube Channel, if you missed the live broadcast.
Within moments, I saw explosions on Facebook about "toxic-chemical based life form" or "arsenic-eating bacteria" –- so this message should have been clearer: THIS IS NOT AN ARSENIC-BASED LIFE FORM, NOR DOES IT EAT ARSENIC.
Of the six accepted components needed for life (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur or CHNOPS), one is missing from these tiny rebels, and in what would normally be considered the phosphate backbone of their DNA helix, they can subsist upon another element that we hitherto considered lethal.

GFAJ-1
Compared to what we generally understand about Deoxyribonucleic Acid, to find a microbe performing differently than all other life as we know it, is startling in its profundity – though perhaps not entirely surprising in the greater realm of biology.
(Retro-viruses, for instance, are so named because they present a reverse transcriptase anomaly, and scientists have found critters who live in steam vents and ice. So, our minds have been pre-stretched by these valuable discoveries. I also try to remember that we have barely cataloged even a fraction of the living species in our oceans; what we know is always dwarfed by what we don't know.)
My first thought was how superbly this displays ADAPTABILITY. A bacterium took something from its ecosystem that is considered poisonous, used it to its advantage, then created similarly capable progeny. Other bacteria might die under such conditions, but one little chap found a way to survive, and this is a fine demonstration of natural selection right before our very eyes.
We aren't truly "re-writing" the rules as we find such delightful exceptions, we're just getting all the rules straight! I particularly liked her anecdote: "It's thinking about life in a planetary context." Quite so. When we look elsewhere for life, we must broaden the scope of possibilities. We are always seeking to find the "constants" on our own planet, and entertaining the notion that "constants" may be different elsewhere.
My other favorite quotable moment was ecologist Dr. James Elser, both complimenting and mildly admonishing Simon-Wolfe, when he cracked, "We thank you and blame you for making our lives more difficult!"

I don't think it will be as difficult as he surmises, however. We will see multiple scientific studies attempting to verify the results, and see if any other bacteria can be encouraged to make exotic substitutions. We have already found in other areas of study that adaptability is highly variable... so while many people are considering this an Earth-shattering finding right now, what will ultimately measure its success is the day we find it "mundane."
NASA Goddard Astrobiologist Pamela Conrad summed this up artfully: "This makes me have to expand my notion of what environmental constituents might enable habitability."
What is essential to life and what is simply tolerated chemically? What are the metrics for habitability, and if new ones developed, can they be passed on genetically? What is downright essential? What is unlikely or impossible? We keep thinking we know this. We keep finding out we're on a much longer journey.

Of course, XKCD weighed in, and said what no one else was willing to say aloud -– that at one time or another, we've all fantasized about slipping the general media some arsenic, LOL...

































































8 comments:
I'm very glad you slept on it before just throwing something out there lacking some thought.
You cleared up one misunderstanding I had. I thought the little guys ate arsenic. Don't the ones living off sea vents eat sulfur?
thanks
Me too! It was very satisfying to ruminate. I am disappointed in some of the alleged science outlets who got a lot of the data wrong because of their emphasis on speed over accuracy... even NASA's Science News mailing list called it an "Arsenic BUG". AAAAHHH!! Appalling!
And yes, short version, the bacteria in hydrothermal vents can metabolize sulfur (chemosynthesis as opposed to photosynthesis).
This excites me! There is hope for someday cleaning up the toxic rivers and streams in Northern California left from the gold mines and the monitor dredging they did. A few years back we went to a stream and valley that were blocked because the arsenic was so abundant. Literally, the stream was dead and deadly.
Me too, SGE! And I agree, the practical applications are also crucial. One of the scientists spoke about that very thing during the press conf and could barely get his words out, he was so excited, LOL...
Unfortunately, this seems to be getting lost in a lot of the hyped news stories...
Do these procaryotes still use Adenosine Triphosphate for
respiration ? They still fit my concept of 'organic inorganic
coevolution'.However that's still amongst the most radical biology
news of my life time if true.Substitution of one mineral for another
by an organism is not new however.Some organisms substitute selenium for sulpher into an organic structure when selenium is unavailable,as just one example.
Pretty amazing however still doesn’t hurt the concept of
organic-inorganic coevolution.It almost strengthens it….
Organic-Inorganic Coevolution …
by Tony Ryals
Before life made a cell it must have occurred,
Carbon and minerals wrote their first word,
It was the basis of the biospheric revolution,
Organic-inorganic co-evolution,
From the simplest life-form viral,
To the most complex evolutionary spiral,
Dances within a watery solution,
Using the elements of organic-inorganic co-evolution
Even the genetic strand has the phosphorous mineral in its carbon configuration
Phosphorous holds not only the key to energy transformation,
And life’s respiration
But is also essential to store life’s genetic information,
And eventually human intellectualization,
And what would be chlorophyll,
Without magnesium its carbon bonds to fill ?,
Without the magnesium impetus,
There’d be no photosynthesis,
And what would be the enzyme nitrogenase,
Without molybdenum to fill its carbonaceous space,
Nitrogenase alone would lack the inspiration,
To perform prokaryotic nitrogen fixation,
Without molybdenum fertilization,
And long before hemoglobin came along,
Other iron-containing heme groups sang their song,
Before these iron-carbon molecules evolved for respiration,
They protected oxygen-sensitive molecules from oxidation,
After photosynthesis led to oxygen’s liberation,
There’d be no vitamin B-12 or cobalamine,
If cobalt hadn’t co-evolved with carbon
To make this vitamin,
And what to the biosphere would it have meant,
If selenium hadn’t evolved with carbon
to form an anti-oxidant,
Molybdenum calcium iron and sulfur,
Chromium magnesium potassium copper,
Liebig’s law of the minimum,
And law of the maximum,
You can’t have too much and you can’t have too little,
You must be somewhere in the middle,
Copper in feed lots makes pigs grow fast,
But then their copper-loaded excrement poisons the grass,
Can’t survive the future without respecting the biosphere’s past,
The traces of life are in your head,
Bacteria will use them when you’re dead.
http://malta.indymedia.org/node/8810
As scientifically interesting and exciting as this find is, the media hype blew the discovery way out of proportion. Discoveries of "extremophile" organisms on Earth have been going on with great frequency since the late 70s. Plus, this bacteria was coached to like arsenic in the lab, not nature. Furthermore, by insinuating a direct link to extraterrestrial life, NASA bordered on misleading the public, so overall, I give NASA a C for this episode.
Brian, I’m quite shocked at your reaction, having read your observational writing for years now. NASA gives grants for just these types of studies for the purpose of understanding how we search and what we search FOR in terms of extra-terrestrial life. They are our SPACE AGENCY, and new probes will be launched toward conspicuously different environments with these goals. They aren't responsible for puerile media sensationalizing the news to cater to the fast-food-two-second-sound-byte common denominator (talk about a given!).
Arsenic is already present in Mono Lake, so I don't think the bacteria were "coached" to like it. They were introduced to a higher level of arsenic and deprived of phosphorus. This absolutely can happen in nature… the difference being that most organisms die. The GFAJ-1 halomonadaceae did not. It integrated an environmental “poison” into its genetic architecture! That is PROFOUND, particularly since phosphorus was previously considered a survivability pre-condition.
The idea of chemical substitutions was postulated decades ago – the publishing scientist herself said that. No one is surprised that biological organisms invent different ways to survive via mutation or adaptation. Cite: Leclerc 1789, Darwin / Wallace 1856. However, the key is creating offspring who can do the same thing without dying or being infertile.
This was not merely an extremophile (certainly those are well-known, as I pointed out above to relay context) but a metallotolerant organism never before observed. That potential for substitution, that very encouraging ability for adaptation, opens up new possibilities for what we think are the “elements necessary for life”. The experiments will of course now be repeated, and confirmed or refuted. Fun for all! =)
Great post! I must say that I was not at all shocked at the press release and the "ADAPTABILITY" :-)
When I think of the scaffolding of DNA, I picture easily modifiable building blocks. Blocks amenable to change.
While I found myself excited about the news, many of my science limited friends had no clue until I gave them the breakdown in an analogy that they could understand.
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